Staphylococcus aureus

Staphylococcus aureus infections are obviously a huge topic.  We broke up the literature into the categories of “bacteremia” and “everything else” to make it easier to keep track of all of the resources. This collection was compiled by @DrH_flu and others.  Please let us know if there are more papers that you think merit being listed here as “must read” papers for ID fellows. 

Staphylococcus aureus Bacteremia

  • Delay in antibiotics in hospital-acquired SAB increased the risk of mortality and increased length of stay
  • Daptomycin was noninferior to beta-lactam or vancomycin + gentamicin for SAB/IE
  • Higher MIC to vancomycin was associated with higher mortality for both MSSAB and MRSAB
  • Higher MIC to vancomycin was associated with higher mortality for both MSSA IE and MRSA IE
  • Early valve surgery was not associated with lower mortality rate in patients with S. aureus PVIE
  • The longer the bacteremia, the higher the mortality. Delay in source control led to increased mortality

Everything Else S. aureus

MRSA infections in adults and children

S. aureus infections

S. aureus comprehensive review

Beta-lactam therapy for MSSA; inoculum effect with cefazolin

Beta-lactam therapy for MSSA; inoculum effect with cefazolin

TMP-SMX for MRSA

Cefazolin = anti-staph PCNs for MSSA infections

TMP-SMX may be an effective option for severe S. aureus infections including bacteremia

Linezolid might be better than vancomycin for cSSTI but it’s hard to tell; more adverse events

Linezolid was more effective than vancomycin for cSSTI but no difference in bacteremia

Linezolid was not superior but no worse than vancomycin for MRSA nosocomial pneumonia

SA-infected orthopedic implants with fusidic acid or oflaxacin + rifampin

Rifampin for treatment of orthopedic implant infections (randomized controlled)

Switch to PO = >4 weeks of IV for S. aureus OM, better with rifampin either with IV or PO

hVISA MRSA in IE was fairly common

Mortality was higher in S. aureus PVIE treated medically compared to surgically, except no difference in patients <50y

PO FQ + rifampin = IV for S. aureus infections

Vancomycin was superior to TMP-SMX in treating S. aureus infections (including bacteremia) in PWID, but all failures were in MSSA

Vancomycin was superior to TMP-SMX in treating severe MRSA infection, especially in bacteremia

Linezolid was noninferior to vancomycin for hte treatment of MRSA infections

Linezolid = vancomycin for treatment of MRSA infections and may be more effective in achieving microbiolgical eradication

Linezolid = vancomycin for treatment of cSSTI caused by MRSA

Clindamycin failed for SA endocarditis and led to development of resistance

Rifampicin in treatment of osteoarticular infections

Case report of imipenem/fosfomycin combination for refractory MRSAB and spinal abscess

S. aureus and coagulation system

S. aureus, master manipulator of the coagulation system

Outbreak of linezolid-resistant MRSA, which is very rare, in an ICU that used linezolid heavily

Case series of 10 PWID with right-sided S. aureus IE who were successfully treated with oral cipro + rifampin

Comparing virulence and resistance of varieties of S. aureus

 

 

Postpartum Staph toxic shock syndrome

https://twitter.com/MayoClinicINFD/status/1328185662835666944?s=20

 

MRSA nasal screening had very high NPV for pneumonia

MRSA nasal screening had very high NPV for pneumonia

MRSA nasal screening had very high NPV for pneumonia

MRSA nasal screening had very high NPV for pneumonia

MRSA nasal screening had very high NPV for nosocomial pneumonia

MSSA nasal swabs had a high PPV and NPV for wound infections in the ED

MRSA nasal swabs had very high NPVs for multiple infections; huge study

Let us know in the comments if you have any papers you’d like to add/remove!

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